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Erectile dysfunction

Also known as ED and impotence, the loss of the ability to produce and/or sustain an erection despite adequate stimulation and interest.

Physiology of Erection

penis erection
The penis is made up of 3 chambers, two corpora cavernosa – the erectile tissues and one corpus spongium. Secretion of nitric oxide (NO) leads to sexual arousal, blood vessels dilate and blood fills the penis. This typically lasts until arousal is diminished or orgasm is achieved.

Penile erection is mediated by the nervous system. On stimulation causes vasodilatation and relaxation of the cavernosal (penis) smooth muscle, which ultimately leads to penile erection. Nitric oxide is released from nerve endings by activating guanylate cyclase and resulting into cGMP which is the secondary messenger that causes smooth muscles relaxation leads to venous engorgement and penile tumescence.

Recent research has helped to change our thinking about the most common causes of sexual dysfunction. For a long time it was assumed that almost all erection failures were caused by psychological factors -- stress, anxiety, and fear. While these factors can play a significant role, most experts now believe the major cause of impotence is physical. Simply stated, anything that interferes with blood flow to the sexual organs interferes with sexual function.

It was presumed that almost all erection failures were caused by physiological factors like stress, fear, anxiety etc. Though these factors play a significant role, recent researches also indicate impotence as physical inability of blood flow to the penis.

Physical causes of erectile dysfunction
* Excess use of alcohol and tobacco/nicotine
* Fatigue/anxiety/stress
* Brain or spinal-cord injuries
* Low testosterone levels i.e. Hypogonadism
* Parkinson's disease
* Radiation therapy to the testicles
* Heart stroke/s
* Some types of prostate or bladder surgery
* Hyperglycemia (high blood sugar)
* Hypertension (high blood pressure)

Feelings that can lead to erectile dysfunction
* Nervousness about sex. It could be a result of bad experience or past episode of impotence.
* Stress related to work/family
* Problems in the relation with sex partner
* Depression
* Consciousness and negative feelings

Testosterone and Sex Drive
As age increases, men usually suffer from low sex drive, poor stamina and lack of sexual interest, because most of the testosterone gets bound by sex hormone building globulin. Only 2% of testosterone are left free which are responsible for providing the body with energy and sex drive. Normal men should have 800 free testosterone and lesser number calls for erectile dysfunction.

Ingredients
provigrax ingredients
Niacin or vitamin B3 helps release of histamine all over the body. Its key role is to dilate blood vessels especially in genital area, so that more and more blood can pass through at given time. Histamine released causes more intense sex flush with simultaneous secretion of mucus in the mouth and genital parts. It also has the ability to increase sensation all over the body, thus increasing overall physical experience.

Niacin also assists in metabolisation and assimilation of fats, proteins and carbohydrates. It reduces serum lipids and involved in synthesis of sex hormones and increase blood circulation.

Vitamin B6 or Pyridoxine is one of the key enzyme cofactors. It is the master vitamin in the processing of amino acids thus proteins and some hormones. It facilitates rapid absorption, nerve impulse transmission and formation of neurotransmitters that effect mental process and elevates mood levels.

Vitamin B6 is necessary for metabolism of lipids, carbohydrates and proteins and helps synthesis of hemoglobin and normal function of RBCs. It helps prevent the onset of arteriosclerosis. It helps clear plaque from blood vessels thus allowing greater blood volume to flow to the penis during arousal. Hence resulting into an erection which is firmer, harder and longer lasting.

L-arginine is a vital amino acid that releases human growth hormone leads to increase in length and girth of the penis. While it enhances circulation resulting into improved blood flow to the genital area, it also improves sperm count, seminal volume and motility.

Aside from bolstering immune systems, it increases protein synthesis which is essential for cell replication and increased sperm count. Dilation of blood vessels is critical for firm erection; depends on nitric oxide, aided by L-arginine. The nutrient is considered as most effect natural supplement for increasing male libido.

Current studies support the use of L-arginine supplements to ensure that nitric oxide secretion is sufficient to keep blood flowing to the penis.

L -Phenylalanine (LPA) is converted to phenylethylamine, function as antidepressant and creates a positive and elevated mood. Also improves memory, concentration and sense of well being.

L-Phenylethylamine further gets converted to L-tyrosine in liver, and L-tyrosine get converted by neurons in the brain to dopamine, epinephrine and norepinephrine hormones which are deleted by stress, overwork and certain drugs. By replenishing norepinepherine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. Liver conversion of LPA leads into faster acting L-tyrosine, further conversion to norepinephrine may be enhanced in the presence of vitamin B6.

Epimedium
Epimedium Or Horny Goat Weed holds an important place in traditional Chinese medicine, now gaining popularity throughout the world for its role in restoring sexual life, boosting erectile function, allaying fatigue and depression.

Termed as most valuable herbal tonic, epimedium supports healthy sexual activity, helps boost libido and improve erectile function. It works by freeing up testosterones which are responsible for sex drive and endurance. It tones up kidneys and reduces symptoms of impotence, frequent urination and lower back pain.

Clinical researches prove that epimedium increase sexual activity, enhance sperm production and have a moderate androgen like influence on the testes, prostate gland and genital muscles thus influencing desire and interest for sexual activity.

Researches also show that Epimedium can inhibit an enzyme called acetylcholinesterase (AChE). By inhibiting AChE, Epimedium supports higher levels of the key cholinergic neurotransmitters associated with sexual arousal.

Trials prove that usage of epimedium elevates the levels of noradrenalin, adrenaline, serotonin and dopamine, thus encouraging release of LH which in turn stimulates testes to produce more testosterone. Also associated with stimulation of sensory nerves particularly genital region.

MACA (Lepidium meyenii)
Maca is an all-natural herbal wonder from Peru with a legendary history for its use to increase sexual ability, pleasure, endurance, mental clarity and most important as an aphrodisiac. Maca contains 50 naturally occurring phyto-chemicals including vital hormonal precursors and sterols proven to assist the human body. It is also an adaptogen and creates homeostasis in the body, regulates levels of hormones and enzymes. Also supports enhanced libido, improved potency, fertility and increased DHEA & testosterone levels. It helps overcome depression and alleviate stress.

Maca is a wonderful source of natural vital nutrients. The synergy of so many amino acids, vitamins, and minerals in their natural states may increase the assimilation, uptake, and utilization of them in the body. That’s why Maca is a powerful adaptogen immunostimulant that help balance our body's systems, stabilize blood pressure, boost immunity and harmonize the body's overall vitality.

Primary uses of Maca
1. Aid in fertility and as aphrodisiac 2. Energize and revitalize physical and mental strength.

Doctor's Comments on Maca:
Gary F. Gordon, M.D., former President of the American College for Advance Medicine, now founder and president of the International College of Advanced Longetivity Medicine, located in Chicago, Illinois, know first hand the value of Maca. "We all hear rumors about various products like Maca," he says. "But using this Peruvian root myself, I personally experienced a significant improvement in erectile tissue response.”

Dr. Gordon explains that Maca works by normalizing our steroid hormones like testosterone, progesterone, and estrogen. Therefore it has the facility to forestall the hormonal changes of aging. It acts on men to restore them to a healthy functional status in which they experience a more active libido. While at the same time relaxes the penile muscles thereby allowing blood flow into the penile muscle tissue causing a hard erection


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Medical Terms

Definition for in-house pharmacy
Pharmacy services which are housed within a covered entity's facility. The pharmacy must be part of the legal organization of the covered entity.

Different definition / meanings for the word "new drug application":
An application requesting FDA approval to market a new drug for human use in interstate commerce. The application must contain, among other things, data from specific technical viewpoints for FDA review--including chemistry, pharmacology, medical, biopharmaceutics, statistics, and, for anti-infectives, microbiology.

Different definition / meanings for the word "Anxiety disorders":
Include Panic Attacks, Agoraphobia (avoidance of places or situations in which help may not be available during a panic attack), Specific Phobias (eg, riding an escalator), Social Phobia, Acute Stress Disorder, Posttraumatic Stress Disorder, Obsessive-Compulsive Disorder (OCD), Generalized Anxiety Disorder (GAD), Anxiety Due to a General Medical Condition, Substance-Induced Anxiety Disorder, and Anxiety Disorder Not Otherwise Stated.

Different definition / meanings for the word "Anxiety":
An uncomfortable emotional state in which one perceives danger, feels powerless and experiences tension in preparation for an expected danger. Physical symptoms include increased heart rate, irregular breathing, trembling, and sweating.

 

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